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There is also no unified standard for the types and ratios of cytokines and nutrients during the differentiation process and these factors limit the application prospects of HLC

Compared with healthy controls, 11 SLE patients showed significantly higher levels of Streptococcus , accompanied by reduced abundance of Dialister and Azospirillum [15]

These require prompt medical evaluation

Furthermore, chronic inflammation is recognized as a key factor in inducing insulin resistance, and GPER can modulate intracellular signaling pathways or suppress the expression of proinflammatory cytokines, which reduces the interference of chronic inflammatory responses and improves insulin resistance [1, 34]