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Scientists have hypothesized that targeting those two hormones could have a meaningful effect on weight loss and blood sugar levels with fewer side effects than drugs that only target GLP-1, such as Novo Nordisk's weight loss treatment Wegovy

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Review of published guidelines from the American Diabetes Association (ADA) and American Association of Clinical Endocrinology (AACE) similarly recommended metformin as the first-line treatment for type 2 diabetes, regardless of comorbid conditions [11, 18]

This significantly increases the risk of side effects, such as severe nausea, vomiting, diarrhea, and other potential complications, without offering any additional therapeutic benefits