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SUSTAIN-6 was the first CVOT with a once-weekly GLP-1 receptor agonist and demonstrated significant cardiovascular benefits with a reduction in MACE and non-fatal stroke, and an unexpected increase in diabetic retinopathy

individuals with pre-existing retinopathy should be aware of this risk [28] [29] Pregnancy and breastfeeding incretin-based therapies should be avoided during pregnancy and breastfeeding unless within a supervised clinical trial, as safety data in these populations are absent Delayed gastric emptying a class effect of GLP-1 receptor agonists can reduce the absorption rate of concomitant oral medicines

Since standard tests are not designed to identify this molecule, it effectively goes unnoticed

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