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The ligand parameters were obtained from Automated Topology Builder 34,35

Kidney stones are a type of mineral deposit that forms in the kidneys, causing symptoms like pain, nausea, and vomiting ( Although several types of kidney stones exist, calcium oxalate kidney stones are the most common ( Oxalate is a compound found in many plant foods, including some fruits, vegetables, nuts, and grains ( When you eat oxalate-rich foods, the oxalate in them binds to calcium in your digestive tract and is excreted through your stool or urine

This situation translated into an increased OARSI score, increased secretion of TNF-, increased expression of MMP-13 and COLX and bone marrow lesions [47]

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