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Data from the SURMOUNT trials showed that participants losing significant weight on tirzepatide experienced approximately 33-39% of total weight loss from lean body mass

The Lui group identified an intrinsic LPAAT function in G0S2 which could promote TAG accumulation independent of PNPLA2 inhibition in hepatocytes (20)

484,485 In Costello syndrome, which is a form of RASopathy caused by mutations of the gene encoding HRAS protein, astrocytes are hypertrophic and demonstrate increased proliferative activity

Oral candidiasis in adults is seen following therapy with broad-spectrum antibiotics or inhaled steroids and in people with diabetes, patients who are seriously ill or immunocompromised