Science 364 , 355362 (2019)
In addition, a high-fat diet can significantly increase the level of caspase-3 and decrease the level of bcl-2, which increases the susceptibility of cells to apoptosis and causes a series of obesity-related complications [242, 243]
They tend to be most effective for mild to moderate cases of post-inflammatory hyperpigmentation (think lingering marks after body breakouts, bug bites, or irritation) and uneven tone, especially when formulas contain ingredients like niacinamide, retinol, vitamin C, kojic acid, or exfoliating acids that encourage cell turnover and fade discoloration over time
Marte A, Pintozzi L, Creti G, Chiesa PL, Renzo DD, Gasparella M, Maggio GD, Bagnara V, Merlini E, Tadini B, Caldarulo E, Sangiorgio L, Battaglino G, Nappo SG, Caione P (2017) Long-Term Follow-Up of Testicular Microlithiasis in Children and Adolescents: Multicenter Prospective Cohort Study of the Italian Society of Pediatric Urology