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In these standards there is a clear recommendation, much earlier in the pathway, for the use of SGLT2i/GLP-1 RA combination therapy in those with established or high risk of CVD

Medications to reduce acid production

however approval is not guaranteed and first-movers face high risk USA/Australia & New Zealand/India There may be limited scope to reference GLP-1 through self-substantiated claims, but this carries increased compliance risk For global brands, aligning product positioning, claims and labelling strategies across these differing frameworks will be a key challenge

In 2019, it received FDA approval for reducing the risk of major cardiovascular events in individuals with both diabetes and a history of cardiovascular issues