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CRP is predominantly synthesised in the liver, mainly in response to interleukin-6 (IL-6) and to a lesser extent to interleukin 1 (IL-1) and 17 (IL-17) and tumour necrosis factor alfa (TNF-) (38)

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3.3.1 Parkinsons disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded -synuclein, in dopaminergic neurons and likely contribute to the death of these neurons

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