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Ma LY, Liu SF, Ma ZQ, Guo YG, Li M, Gao Y, Wen YT, Niu Y, Sui HX, Li BS, Li Y, Lv YL, Huang Y, Zhai JJ (2025) Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating -secretase and -secretase and alleviating oxidative stress in HT-22 cells

This is the crux of the dosing question: the failure to replicate cannot be attributed to underdosing relative to the original protocol, because the dose was matched

Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown

The product label, lot-specific COA, and SDS take priority over general guidelines