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It is one of the compounds responsible for the stomach-friendly properties often attributed to darker roasts paradoxically, NMP has been shown in research to inhibit gastric acid secretion, which is why some individuals with acid sensitivity find darker roasts easier on their stomach despite the general specialty coffee preference for lighter profiles

D-Nle-Tyr-Ile-NH (CH 2 )s-CONH 2 is more metabolically stable than Norleual, possesses an elongated half-life in the circulation and penetrates tissue effectively

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