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This strategy has significantly reduced side effects, allowing patients to experience the benefits of GLP-1 medications without the discomfort

These conformational changes are stabilized by additional noncovalent interactions involving the conserved residues, such as the Arg121 making hydrogen bonds with Asp67 to further strengthen the pi-cation interactions involving Trp72, Arg102, and Trp110 (see Figure 4 inset 2)

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